Literature summary extracted from
Montealegre, M.C.; Roh, J.H.; Rae, M.; Davlieva, M.G.; Singh, K.V.; Shamoo, Y.; Murray, B.E.
Differential penicillin-binding protein 5 (PBP5) levels in the Enterococcus faecium clades with different levels of ampicillin resistance (2017), Antimicrob. Agents Chemother., 61, e02034 .
Application
EC Number |
Application |
Comment |
Organism |
---|
3.4.17.8 |
medicine |
PBP5 mRNA and protein levels are increased in subclade A1 and A2 ampicillin-resistant strains compared to those in clade B and subclade A2 ampicillin-susceptible strains. There is evidence of major clade-associated rearrangements in the region upstream of PBP5, including large DNA fragment insertions, deletions, and single nucleotide polymorphisms, that may be associated with the differential regulation of PBP5 levels between the Enterococcus faecium clades |
Enterococcus faecium |
Organism
EC Number |
Organism |
UniProt |
Comment |
Textmining |
---|
3.4.17.8 |
Enterococcus faecium |
A0A075Q0W3 |
- |
- |
Expression
EC Number |
Organism |
Comment |
Expression |
---|
3.4.17.8 |
Enterococcus faecium |
PBP5 mRNA and protein levels are increased in subclade A1 and A2 ampicillin-resistant strains compared to those in clade B and subclade A2 ampicillin-susceptible strains. There is evidence of major clade-associated rearrangements in the region upstream of PBP5, including large DNA fragment insertions, deletions, and single nucleotide polymorphisms, that may be associated with the differential regulation of PBP5 levels between the Enterococcus faecium clades |
additional information |