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Literature summary extracted from

  • Montealegre, M.C.; Roh, J.H.; Rae, M.; Davlieva, M.G.; Singh, K.V.; Shamoo, Y.; Murray, B.E.
    Differential penicillin-binding protein 5 (PBP5) levels in the Enterococcus faecium clades with different levels of ampicillin resistance (2017), Antimicrob. Agents Chemother., 61, e02034 .
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
3.4.17.8 medicine PBP5 mRNA and protein levels are increased in subclade A1 and A2 ampicillin-resistant strains compared to those in clade B and subclade A2 ampicillin-susceptible strains. There is evidence of major clade-associated rearrangements in the region upstream of PBP5, including large DNA fragment insertions, deletions, and single nucleotide polymorphisms, that may be associated with the differential regulation of PBP5 levels between the Enterococcus faecium clades Enterococcus faecium

Organism

EC Number Organism UniProt Comment Textmining
3.4.17.8 Enterococcus faecium A0A075Q0W3
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Expression

EC Number Organism Comment Expression
3.4.17.8 Enterococcus faecium PBP5 mRNA and protein levels are increased in subclade A1 and A2 ampicillin-resistant strains compared to those in clade B and subclade A2 ampicillin-susceptible strains. There is evidence of major clade-associated rearrangements in the region upstream of PBP5, including large DNA fragment insertions, deletions, and single nucleotide polymorphisms, that may be associated with the differential regulation of PBP5 levels between the Enterococcus faecium clades additional information